The Do-Over

Charlie lives in Florida with his materialistic wife, Nikki and her two unpleasant twin sons from her ex husband, Ted-O. He is a bank manager in a supermarket and Nikki is cheating on him with Ted-O. Charlie reunites with his old high school buddy (and FBI agent) Max at a high school reunion. They spend a weekend on a yacht Max rented, and Charlie feels young again.Max blows up the yacht to fake their deaths. When Charlie comes to, Max tells him they can now both start over. He says he is not an FBI agent, but actually a coroner. This allowed him to use two unclaimed cadavers in their place; Charlie is now Dr. Ronald P. Fishman, and Max is Butch Ryder.Initially appalled, Charlie soon realizes a do over is appealing after witnessing his lackluster funeral, Nikki reconciling with Ted-O and the bank has quickly replaced him. Max tells Charlie that he found a key in Butch's rectum, which Charlie determines belongs to a Puerto Rico safe deposit box.Traveling to Puerto Rico, the duo access Butch's safe deposit box, which contains money and the keys to a mansion with a Ferrari. They relocate there, befriending and later having an orgy with neighbors Dawn and Joan during which Dawn reveals the original Butch and Ronald bought the mansion in a hurry, implying they were on the run.They discover Ronald was married after seeing a picture of his wife on Butch's tablet. At the mansion, Max and Charlie are attacked by assassins led by The Gymnast. They escape, and Max admits he's not a coroner, but actually a guidance counselor.They track down Ronald's widow Heather at her home in Savannah, Georgia. The duo explain that Ronald was murdered and believe Butch got him entangled in criminal activity. Heather discloses that Ronald's study was recently broken into.The trio head to a biker bar where Ronald and Butch hung out. There, they learn from the biker Dakota, that Butch had stage four cancer. They had begun conducting secret, non-FDA approved clinical trials Ronald's "magic bullet" cancer treatment. Ronald's financier Shecky withdrew funding, so Butch started robbing banks, making him wanted by the FBI.After Dakota reveals that Ronald and Butch had an affair, he is then killed by The Gymnast. The trio escape to Max's mother's where they are stalked by Max's ex, Becca, and Charlie ends up having sex with Heather. 40 Shecky reveals that his house was also broken into recently. The trio leave, deducing the cancer treatment formula is why men tried to kill them and broke into their homes. Charlie says they should forfeit it when they find it, which angers Max. While hacking Ronald's computer, Charlie discovers Max was one of Ronald's cancer patients. He also learns that Max and Becca have a young son, and realizes Max needs the cure to save his own life.Returning to Shecky's, Max thinks he is withholding the cure. Shecky has been shot, but before he dies, reveals the assassins were hired by Trojgaard, the world's largest chemotherapy company, to steal the cure and bury it. The Gymnast, still in the house, takes Max hostage.Meanwhile, Charlie realizes the Jenga app on Butch's tablet actually holds the cure. He attempts to call Max, but The Gymnast destroys his phone as he tortures him. Heather then arrives at Shecky's, telling Max that she not only accepted a fortune from Trojgaard to bury the formula when Ronald refused, but also killed Ronald and Butch.Charlie calls Heather, who claims Max killed Shecky. When he arrives, realizing she's lying, he punches her in the face. She then holds him at gunpoint but, before she can shoot, Max knocks her down. Heather then aims at them both, but Becca shows up, beats her unconscious, and recovers the tablet. The police arrive, and when they draw their weapons, Becca accidentally throws the tablet into the bay as she puts up her hands.The tablet suffers irreparable damage, but Charlie backed up the formula on a USB. The men are pardoned for their crimes when they offer the cancer treatment as a bargaining chip. Charlie disguises himself as a zombie and gets revenge on Nikki, Ted-O and the twins. Charlie, Max, Becca, son and mother return to the mansion in Puerto Rico after Max is cured.